| PRESEASON | |||||
|---|---|---|---|---|---|
| Wk | Date Time/Media | Away | Score | Home | Last Meeting |
| P1 | Sat Aug 15 1:00 PM | Carolina Panthers | - | Buffalo Bills | |
| P2 | Sat Aug 22 1:00 PM | Buffalo Bills | - | Cleveland Browns | |
| P3 | Thu Aug 27 7:00 PM | Pittsburgh Steelers | - | Buffalo Bills | |
| REGULAR SEASON | |||||
| Wk | Date Time/Media | Away | Score | Home | Last Meeting |
| 1 | Sun Sep 13 1:00 PM | Buffalo Bills | - | Houston Texans | 11/20/2025 @HOU HOU: 23-19 |
| 2 | Thu Sep 17 8:15 PM | Detroit Lions | - | Buffalo Bills | 12/15/2024 @DET BUF: 48-42 |
| 3 | Sun Sep 27 1:00 PM | Los Angeles Chargers | - | Buffalo Bills | 12/23/2023 @LAC BUF: 24-22 |
| 4 | Sun Oct 4 1:00 PM | New England Patriots | - | Buffalo Bills | 12/14/2025 @NE BUF: 35-31 |
| 5 | Mon Oct 12 8:15 PM | Buffalo Bills | - | Los Angeles Rams | 12/8/2024 @LAR LAR: 44-42 |
| 6 | Sun Oct 18 4:25 PM | Buffalo Bills | - | Las Vegas Raiders | 9/17/2023 @BUF BUF: 38-10 |
| BYE WEEK 7 | |||||
| 8 | Sun Nov 1 1:00 PM | Baltimore Ravens | - | Buffalo Bills | 9/7/2025 @BUF BUF: 41-40 |
| 9 | Mon Nov 9 8:15 PM | Buffalo Bills | - | Minnesota Vikings | 11/13/2022 @BUF MIN: 33-30 |
| 10 | Sun Nov 15 1:00 PM | Buffalo Bills | - | New York Jets | 1/4/2026 @BUF BUF: 35-8 |
| 11 | Sun Nov 22 1:00 PM | Miami Dolphins | - | Buffalo Bills | 11/9/2025 @MIA MIA: 30-13 |
| 12 | Thu Nov 26 8:20 PM | Kansas City Chiefs | - | Buffalo Bills | 11/2/2025 @BUF BUF: 28-21 |
| 13 | Sun Dec 6 4:25 PM | Buffalo Bills | - | New England Patriots | 12/14/2025 @NE BUF: 35-31 |
| 14 | Sun Dec 13 8:20 PM | Buffalo Bills | - | Green Bay Packers | 10/30/2022 @BUF BUF: 27-17 |
| 15 | Sat Dec 19 8:20 PM | Chicago Bears | - | Buffalo Bills | 12/24/2022 @CHI BUF: 35-13 |
| 16 | Fri Dec 25 4:30 PM | Buffalo Bills | - | Denver Broncos | 1/17/2026 @DEN DEN: 33-30 |
| 17 | Sun Jan 3 1:00 PM | Buffalo Bills | - | Miami Dolphins | 11/9/2025 @MIA MIA: 30-13 |
| 18 | TBD TBD | New York Jets | - | Buffalo Bills | 1/4/2026 @BUF BUF: 35-8 |