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NFL Series Records
Last 20 Years Arizona Cardinals vs San Francisco 49ers (49ers 21-19-0)
Click scores for game stats. Helmets courtesy The Helmet Project.
SeasonDateWeekAwayScoreHome
2026TBD18San Francisco 49ers  Arizona Cardinals
2026Sun
Sep 27, 2026		3Arizona Cardinals  San Francisco 49ers
2025Sun
Nov 16, 2025		11San Francisco 49ers -3½ 41-22Arizona Cardinals (48½)
2025Sun
Sep 21, 2025		3Arizona Cardinals (44½)15-16San Francisco 49ers -1½ 
2024Sun
Jan 5, 2025		18San Francisco 49ers (42½)24-47Arizona Cardinals -4½ 
2024Sun
Oct 6, 2024		5Arizona Cardinals (48½) 24-23San Francisco 49ers -7½
2023Sun
Dec 17, 2023		15San Francisco 49ers -12½ 45-29Arizona Cardinals (48)
2023Sun
Oct 1, 2023		4Arizona Cardinals (43½)16-35San Francisco 49ers -14 
2022Sun
Jan 8, 2023		18Arizona Cardinals (39½)13-38San Francisco 49ers -14½ 
2022Mon
Nov 21, 2022		11San Francisco 49ers -8½ 38-10Arizona Cardinals (43½)
2021Sun
Nov 7, 2021		9Arizona Cardinals (45) 31-17San Francisco 49ers -3½
2021Sun
Oct 10, 2021		5San Francisco 49ers (48½)10-17Arizona Cardinals -5½ 
2020Sat
Dec 26, 2020		16San Francisco 49ers (48½) 20-12Arizona Cardinals -5
2020Sun
Sep 13, 2020		1Arizona Cardinals (48½) 24-20San Francisco 49ers -7
2019Sun
Nov 17, 2019		11Arizona Cardinals (44)26-36San Francisco 49ers -10 
2019Thu
Oct 31, 2019		9San Francisco 49ers -10 28-25Arizona Cardinals (43)
2018Sun
Oct 28, 2018		8San Francisco 49ers -2½15-18Arizona Cardinals (40) 
2018Sun
Oct 7, 2018		5Arizona Cardinals (40½) 28-18San Francisco 49ers -3
2017Sun
Nov 5, 2017		9Arizona Cardinals -2½ 20-10San Francisco 49ers
2017Sun
Oct 1, 2017		4San Francisco 49ers15-18Arizona Cardinals -6½ 
2016Sun
Nov 13, 2016		10San Francisco 49ers20-23Arizona Cardinals 
2016Thu
Oct 6, 2016		5Arizona Cardinals 33-21San Francisco 49ers
2015Sun
Nov 29, 2015		12Arizona Cardinals 19-13San Francisco 49ers
2015Sun
Sep 27, 2015		3San Francisco 49ers 7-47Arizona Cardinals 
2014Sun
Dec 28, 2014		17Arizona Cardinals17-20San Francisco 49ers 
2014Sun
Sep 21, 2014		3San Francisco 49ers14-23Arizona Cardinals 
2013Sun
Dec 29, 2013		17San Francisco 49ers 23-20Arizona Cardinals
2013Sun
Oct 13, 2013		6Arizona Cardinals20-32San Francisco 49ers 
2012Sun
Dec 30, 2012		17Arizona Cardinals13-27San Francisco 49ers 
2012Mon
Oct 29, 2012		8San Francisco 49ers 24- 3Arizona Cardinals
2011Sun
Dec 11, 2011		14San Francisco 49ers19-21Arizona Cardinals 
2011Sun
Nov 20, 2011		11Arizona Cardinals 7-23San Francisco 49ers 
2010Sun
Jan 2, 2011		17Arizona Cardinals 7-38San Francisco 49ers 
2010Mon
Nov 29, 2010		12San Francisco 49ers 27- 6Arizona Cardinals
2009Mon
Dec 14, 2009		14Arizona Cardinals 9-24San Francisco 49ers 
2009Sun
Sep 13, 2009		1San Francisco 49ers 20-16Arizona Cardinals
2008Mon
Nov 10, 2008		10San Francisco 49ers24-29Arizona Cardinals 
2008Sun
Sep 7, 2008		1Arizona Cardinals 23-13San Francisco 49ers
2007Sun
Nov 25, 2007		12San Francisco 49ers 37-31Arizona Cardinals
2007Mon
Sep 10, 2007		1Arizona Cardinals17-20San Francisco 49ers 
2006Sun
Dec 24, 2006		16Arizona Cardinals 26-20San Francisco 49ers
2006Sun
Sep 10, 2006		1San Francisco 49ers (43½)27-34Arizona Cardinals -9½